Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques
Identifieur interne : 002376 ( Main/Exploration ); précédent : 002375; suivant : 002377Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques
Auteurs : LI LIU [Hong Kong] ; QIANG WEI [République populaire de Chine] ; Xavier Alvarez [États-Unis] ; HAIBO WANG [Hong Kong] ; YANHUA DU [Hong Kong] ; HUA ZHU [République populaire de Chine] ; HONG JIANG [République populaire de Chine] ; JINGYING ZHOU [Hong Kong] ; Pokman Lam [Hong Kong] ; LINQI ZHANG [République populaire de Chine] ; Andrew Lackner [États-Unis] ; CHUAN QIN [République populaire de Chine] ; ZHIWEI CHEN [Hong Kong]Source :
- Journal of virology [ 0022-538X ] ; 2011.
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Abstract
The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2+) cells were widely distributed in the upper respiratory tract, and ACE2+ epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques</title><author><name sortKey="Li Liu" sort="Li Liu" uniqKey="Li Liu" last="Li Liu">LI LIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Qiang Wei" sort="Qiang Wei" uniqKey="Qiang Wei" last="Qiang Wei">QIANG WEI</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) 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Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 5, Panjiayuan, Nanli, Chaoyang District</s1><s2>Beijing</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hong Jiang" sort="Hong Jiang" uniqKey="Hong Jiang" last="Hong Jiang">HONG JIANG</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 5, Panjiayuan, Nanli, Chaoyang District</s1><s2>Beijing</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jingying Zhou" sort="Jingying Zhou" uniqKey="Jingying Zhou" last="Jingying Zhou">JINGYING ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lam, Pokman" sort="Lam, Pokman" uniqKey="Lam P" first="Pokman" last="Lam">Pokman Lam</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Linqi Zhang" sort="Linqi Zhang" uniqKey="Linqi Zhang" last="Linqi Zhang">LINQI ZHANG</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Comprehensive AIDS Research Center, Tsinghua University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lackner, Andrew" sort="Lackner, Andrew" uniqKey="Lackner A" first="Andrew" last="Lackner">Andrew Lackner</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Division of Comparative Pathology, Tulane National Primate Research Center</s1><s2>Covington, Louisiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Chuan Qin" sort="Chuan Qin" uniqKey="Chuan Qin" last="Chuan Qin">CHUAN QIN</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 5, Panjiayuan, Nanli, Chaoyang District</s1><s2>Beijing</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhiwei Chen" sort="Zhiwei Chen" uniqKey="Zhiwei Chen" last="Zhiwei Chen">ZHIWEI CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Microbiology and Research Center for Infection and Immunology, Li Ka Shing Faculty of Medicine, The University of Hong King</s1><s3>HKG</s3><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology and Research Center for Infection and Immunology, Li Ka Shing Faculty of Medicine, The University of Hong King</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0211360</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0211360 INIST</idno><idno type="RBID">Pascal:11-0211360</idno><idno type="wicri:Area/PascalFrancis/Corpus">000114</idno><idno type="wicri:Area/PascalFrancis/Curation">000874</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000097</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000097</idno><idno 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Kong</wicri:noRegion></affiliation></author><author><name sortKey="Qiang Wei" sort="Qiang Wei" uniqKey="Qiang Wei" last="Qiang Wei">QIANG WEI</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 5, Panjiayuan, Nanli, Chaoyang District</s1><s2>Beijing</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Alvarez, Xavier" sort="Alvarez, Xavier" uniqKey="Alvarez X" first="Xavier" last="Alvarez">Xavier Alvarez</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Division of Comparative Pathology, Tulane National Primate Research Center</s1><s2>Covington, Louisiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Haibo Wang" sort="Haibo Wang" uniqKey="Haibo Wang" last="Haibo Wang">HAIBO WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yanhua Du" sort="Yanhua Du" uniqKey="Yanhua Du" last="Yanhua Du">YANHUA DU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Hua Zhu" sort="Hua Zhu" uniqKey="Hua Zhu" last="Hua Zhu">HUA ZHU</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 5, Panjiayuan, Nanli, Chaoyang District</s1><s2>Beijing</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hong Jiang" sort="Hong Jiang" uniqKey="Hong Jiang" last="Hong Jiang">HONG JIANG</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 5, Panjiayuan, Nanli, Chaoyang District</s1><s2>Beijing</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jingying Zhou" sort="Jingying Zhou" uniqKey="Jingying Zhou" last="Jingying Zhou">JINGYING ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lam, Pokman" sort="Lam, Pokman" uniqKey="Lam P" first="Pokman" last="Lam">Pokman Lam</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Linqi Zhang" sort="Linqi Zhang" uniqKey="Linqi Zhang" last="Linqi Zhang">LINQI ZHANG</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Comprehensive AIDS Research Center, Tsinghua University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lackner, Andrew" sort="Lackner, Andrew" uniqKey="Lackner A" first="Andrew" last="Lackner">Andrew Lackner</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Division of Comparative Pathology, Tulane National Primate Research Center</s1><s2>Covington, Louisiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Chuan Qin" sort="Chuan Qin" uniqKey="Chuan Qin" last="Chuan Qin">CHUAN QIN</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Laboratory Animal Science Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 5, Panjiayuan, Nanli, Chaoyang District</s1><s2>Beijing</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhiwei Chen" sort="Zhiwei Chen" uniqKey="Zhiwei Chen" last="Zhiwei Chen">ZHIWEI CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Microbiology and Research Center for Infection and Immunology, Li Ka Shing Faculty of Medicine, The University of Hong King</s1><s3>HKG</s3><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology and Research Center for Infection and Immunology, Li Ka Shing Faculty of Medicine, The University of Hong King</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Epithelial cell</term><term>Macaca mulatta</term><term>Respiratory disease</term><term>Severe acute respiratory syndrome</term><term>Target cell</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Macaca mulatta</term><term>Cellule épithéliale</term><term>Cellule cible</term><term>Pathologie de l'appareil respiratoire</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2<sup>+</sup>) cells were widely distributed in the upper respiratory tract, and ACE2<sup>+</sup> epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Louisiane</li></region><settlement><li>Pékin</li></settlement></list><tree><country name="Hong Kong"><noRegion><name sortKey="Li Liu" sort="Li Liu" uniqKey="Li Liu" last="Li Liu">LI LIU</name></noRegion><name sortKey="Haibo Wang" sort="Haibo Wang" uniqKey="Haibo Wang" last="Haibo Wang">HAIBO WANG</name><name sortKey="Jingying Zhou" sort="Jingying Zhou" uniqKey="Jingying Zhou" last="Jingying Zhou">JINGYING ZHOU</name><name sortKey="Lam, Pokman" sort="Lam, Pokman" uniqKey="Lam P" first="Pokman" last="Lam">Pokman Lam</name><name sortKey="Yanhua Du" sort="Yanhua Du" uniqKey="Yanhua Du" last="Yanhua Du">YANHUA DU</name><name sortKey="Zhiwei Chen" sort="Zhiwei Chen" uniqKey="Zhiwei Chen" last="Zhiwei Chen">ZHIWEI CHEN</name><name sortKey="Zhiwei Chen" sort="Zhiwei Chen" uniqKey="Zhiwei Chen" last="Zhiwei Chen">ZHIWEI CHEN</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Qiang Wei" sort="Qiang Wei" uniqKey="Qiang Wei" last="Qiang Wei">QIANG WEI</name></noRegion><name sortKey="Chuan Qin" sort="Chuan Qin" uniqKey="Chuan Qin" last="Chuan Qin">CHUAN QIN</name><name sortKey="Hong Jiang" sort="Hong Jiang" uniqKey="Hong Jiang" last="Hong Jiang">HONG JIANG</name><name sortKey="Hua Zhu" sort="Hua Zhu" uniqKey="Hua Zhu" last="Hua Zhu">HUA ZHU</name><name sortKey="Linqi Zhang" sort="Linqi Zhang" uniqKey="Linqi Zhang" last="Linqi Zhang">LINQI ZHANG</name></country><country name="États-Unis"><region name="Louisiane"><name sortKey="Alvarez, Xavier" sort="Alvarez, Xavier" uniqKey="Alvarez X" first="Xavier" last="Alvarez">Xavier Alvarez</name></region><name sortKey="Lackner, Andrew" sort="Lackner, Andrew" uniqKey="Lackner A" first="Andrew" last="Lackner">Andrew Lackner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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